Efficacy of zinc therapy in prevention of crisis in sickle cell anemia: a double blind, randomized controlled clinical trial

Autor:	V L, Gupta, B S, Chaubey
Rok vydání:	1995
Předmět:	Adult Male Adolescent Sulfates Administration Oral Capsules Anemia Sickle Cell Bacterial Infections Length of Stay Zinc Sulfate Placebos Zinc Treatment Outcome Double-Blind Method Antisickling Agents Zinc Compounds Confidence Intervals Humans Female Follow-Up Studies
Zdroj:	The Journal of the Association of Physicians of India. 43(7)
ISSN:	0004-5772
Popis:	145 patients were recruited in the trial while 130 completed it. Patients were randomized to receive zinc sulphate capsules. 220 mgm three times a day or identical placebo. Major outcome variable was 'Sickle cell crisis'. After a follow up of 1.5 years, the mean number of episodes of crisis was 2.46 +/- 1.04 in the intervention group and 5.29 +/- 2.58 in the control group (p0.025; 95% CI for difference between groups: 1.98, 3.42). Mean duration of hospital stay was 4.3 +/- 2.2 days in the intervention group and 3.9 +/- 1.6 days in the control group. The difference was not significant (p0.05). There was a significant reduction of the mean number of infective episodes and associated morbidity in patients with sickle cell anaemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::640b42b896f6265217af3c85ab2b0745 https://pubmed.ncbi.nlm.nih.gov/8713219 Zobrazit plný text záznamu