| Autor: |
Hatice, Sahin, Ebru, Gok Oguz, Hadim, Akoglu, Gokhan, Atilgan, Gulay, Ulusal Okyay, Guner, Karaveli Gursoy, Tugba, Kip Teymur, Dilek, Ertoy, Basol, Canbakan, Mehmet Deniz, Ayli |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Iranian journal of kidney diseases. 12(5) |
| ISSN: |
1735-8604 |
| Popis: |
Two-thirds of complement C3 glomerulopathy (C3G) recur after transplantation and commonly cause graft loss. There is not a standard treatment protocol for these cases. We present a kidney transplant patient with recurrent C3G who was successfully treated with eculizumab. Nephrotic proteinuria and hematuria occurred and creatinine levels increased after transplantation. A graft biopsy revealed recurrent C3G. The patient was administered 250 mg pulse methylprednisolone for 3 days and had 9 sessions of plasmapheresis. Since elevated creatinine levels and proteinuria persisted, eculizumab was instituted. A complete remission was observed after 9-month maintenance eculizumab treatment. Eculizumab may be a potentially effective option in kidney transplant patients with recurrent C3G unresponsive to other treatment modalities. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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