| Autor: |
Kelsey C, Benton, Daniel S, Wheeler, Beliz, Kurtoglu, Mahshid Bagher Zadeh, Ansari, Daniel P, Cibich, Dante A, Gonzalez, Matthew R, Herbst, Saema, Khursheed, Rachel C, Knorr, Doug, Lobner, Jenree G, Maglasang, Kayla E, Rohr, Analisa, Taylor, Robert C, Twining, Paul J, Witt, Paul J, Gasser |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Glia. 70(9) |
| ISSN: |
1098-1136 |
| Popis: |
Norepinephrine exerts powerful influences on the metabolic, neuroprotective and immunoregulatory functions of astrocytes. Until recently, all effects of norepinephrine were believed to be mediated by receptors localized exclusively to the plasma membrane. However, recent studies in cardiomyocytes have identified adrenergic receptors localized to intracellular membranes, including Golgi and inner nuclear membranes, and have shown that norepinephrine can access these receptors via transporter-mediated uptake. We recently identified a high-capacity norepinephrine transporter, organic cation transporter 3 (OCT3), densely localized to outer nuclear membranes in astrocytes, suggesting that adrenergic signaling may also occur at the inner nuclear membrane in these cells. Here, we used immunofluorescence and western blot to show that β |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text