| Popis: |
To assess effects of epiphysial hormone melatonin in various dose regimens on ADP-induced aggregation of platelets in patients with bronchial asthma (BA). Correlations with urine levels of 6-sulphatoxymelatonin (6-SOMT), basic melatonin metabolite, were made.Melatonin was given to 17 patients with mild or moderate BA and 16 healthy controls.BA patients were found to have disorders in circadian rhythm of urine 6-SOMT excretion, lack of correlation between platelet functional activity and elevated nocturnal excretion of 6-SOMT, in vitro platelet activation in response to low-dose melatonin and absence of this reaction to high-dose melatonin.It is suggested that melatonin may be involved in genesis of bronchoobstructive syndrome in BA. |
