| Autor: |
P D, Deepalakshmi, K, Parasakthy, S, Shanthi, N S, Devaraj |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Indian journal of experimental biology. 32(11) |
| ISSN: |
0019-5189 |
| Popis: |
Chloroquine causes an increase in phospholipid and a decrease in cholesterol in liver mitochondria. A significant decrease in the activities of mitochondrial inner membrane enzymes such as NADH dehydrogenase, succinate dehydrogenase and cytochrome c oxidase is observed. Decrease in cytochrome contents and respiratory control ratio, shown by a decrease in state 3(+ADP) and an increase in state 4 (-ADP), implies decreased ATP synthesis following chloroquine administration. The results confirm drug-induced inhibition of mitochondrial respiration, thereby impairing availability and utilisation of energy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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