| Autor: |
Ling, Yang, Wen-Xin, Fan, E, Lin, Dong-Hang, Tan, Qingjiang, Li, Honggen, Wang |
| Rok vydání: |
2018 |
| Zdroj: |
Chemical communications (Cambridge, England). 54(46) |
| ISSN: |
1364-548X |
| Popis: |
A novel synthesis of α-CF3 and α-CF2H amines via the aminofluorination of gem-difluoroalkenes and mono-fluoroalkenes, respectively, is reported. The method employs Selectfluor as an electrophilic fluorine source and acetonitrile as a nitrogen source. Mechanistic studies revealed a single-electron oxidation/fluorine-abstraction/Ritter-type amination pathway. The protocol allowed the synthesis of a broad range of fluorinated amines including those bearing quaternary carbon centers with good efficiency and functional group tolerance. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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