| Autor: |
O, Chol, A, Deroux, A, Bosseray, C, Dumestre-Perard, S, Quetant, A, Bocquet, L, Bouillet |
| Jazyk: |
francouzština |
| Rok vydání: |
2022 |
| Zdroj: |
La Revue de medecine interne. |
| ISSN: |
1768-3122 |
| Popis: |
Idiopathic inflammatory myopathies (IMM) are rare diseases with clinico-biological heterogeneity. Pulmonary involvement is frequent and associated with some distinctive manifestations. The aim of this study was to describe the clinico-biological profile of patients with autoimmune myositis with and without pulmonary involvement.This retrospective descriptive study included patients with idiopathic inflammatory myopathies and a positive antibody test performed at Grenoble Alpes University Hospital between 2010 and 2020.Forty patients were included, the majority were women. The anti-Jo1 autoantibody was the most frequently found (37.5%). The prevalence of pulmonary involvement was 70%. Mechanics' hands and Raynaud's syndrome were the extra-respiratory signs significantly more present in the group with lung involvement (P0.05), in contrast to creatine kinase levels which were lower in this group (P0.05). Glucocorticoids and rituximab were significantly more often used in the group with lung involvement (P0.05). The 5-year survival rate was 76.2% in patients with lung involvement and 100% in patients without lung involvement (P=0.50).We report a high prevalence of lung involvement probably explained by the presence of many patients with anti-synthetase syndrome. Our study highlights a lower severity of muscle involvement in myositis patients with lung disease, which deserves to be confirmed in a larger study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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