The Importance of Probe Location for the Interpretation of Cerebral Microdialysis Data in Subarachnoid Hemorrhage Patients
| Autor: | Mario, Kofler, Maxime, Gaasch, Verena, Rass, Alois J, Schiefecker, Bogdan, Ianosi, Anna, Lindner, Ronny, Beer, John F, Stover, Paul, Rhomberg, Bettina, Pfausler, Claudius, Thomé, Erich, Schmutzhard, Raimund, Helbok |
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| Rok vydání: | 2019 |
| Předmět: |
Glycerol
Male Cerebral microdialysis Microdialysis Glutamic Acid Brain Edema Cerebral metabolism Aneurysm Ruptured Brain Ischemia Cohort Studies Stress Physiological Pyruvic Acid Humans Subarachnoid hemorrhage Lactic Acid Prospective Studies Secondary brain injury Computed tomography Aged Monitoring Physiologic Retrospective Studies Brain Intracranial Aneurysm Middle Aged Mitochondria Glucose Female Original Work Hydrocephalus |
| Zdroj: | Neurocritical Care |
| ISSN: | 1556-0961 |
| Popis: | Background There is no uniform definition for cerebral microdialysis (CMD) probe location with respect to focal brain lesions, and the impact of CMD-probe location on measured molecule concentrations is unclear. Methods We retrospectively analyzed data of 51 consecutive subarachnoid hemorrhage patients with CMD-monitoring between 2010 and 2016 included in a prospective observational cohort study. Microdialysis probe location was assessed on all brain computed tomography (CT) scans performed during CMD-monitoring and defined as perilesional in the presence of a focal hypodense or hyperdense lesion within a 1-cm radius of the gold tip of the CMD-probe, or otherwise as normal-appearing brain tissue. Results Probe location was detected in normal-appearing brain tissue on 53/143 (37%) and in perilesional location on 90/143 (63%) CT scans. In the perilesional area, CMD-glucose levels were lower (p = 0.003), whereas CMD-lactate (p = 0.002), CMD-lactate-to-pyruvate-ratio (LPR; p |
| Databáze: | OpenAIRE |
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