| Autor: |
Desmond O, Agwunobi, Mengxue, Li, Ningmei, Wang, Guomin, Chang, Xiaojing, Zhang, Xiaomin, Xue, Zhijun, Yu, Hui, Wang, Jingze, Liu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ProteomicsREFERENCES. 22(13-14) |
| ISSN: |
1615-9861 |
| Popis: |
Complex mixtures of bioactive ingredients in plant essential oils present complex chemistries which involve different modes of action. An increasing body of scientific reports has recently focused on the acaricidal activities of plant essential oils attributed to their monoterpene components, but information about their underlying molecular mechanism of action is scarce. Here, after the chemical analysis of lemongrass oil, a proteomic analysis of the ovary, salivary gland, and midgut of Haemaphysalis longicornis exposed to Cymbopogon citratus (lemongrass) essential oil was performed via data-independent acquisition mass spectrometry (DIA-MS) technology to further elucidate the molecular mechanisms involved. Pathway analysis reveals the activation of metabolic pathways mediated by oxidoreductases and transferases. Furthermore, the upregulation of various calcium-associated proteins and the upregulation of cytochrome c1, cytochrome c oxidase polypeptide IV, and programmed cell death protein 6-like isoform X1 suggest a cytotoxic mode of action via the formation of reactive oxygen species (ROS), mitochondrial Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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