Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese
| Autor: | Wen-Long, Bao, Hua, Shi, Ai-Qin, Zhang, Xiang-Ming, Kong, De-Hou, Deng, Yong-Jun, Zhang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Lung Neoplasms Adolescent Adenocarcinoma Real-Time Polymerase Chain Reaction Polymorphism Single Nucleotide Young Adult Asian People Risk Factors Carcinoma Non-Small-Cell Lung Humans Genetic Predisposition to Disease Child Aged Interleukin-15 Interleukin-13 Receptors Interleukin-7 Smoking DNA Middle Aged Prognosis Case-Control Studies Carcinoma Squamous Cell Female Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 12(12) |
| ISSN: | 2476-762X |
| Popis: | Studies have shown that immune cells play a key role in lung cancer development. Five SNPs (rs1494555, rs7737000, rs20541, rs1057972 and rs2857261) are associated with lung cancer risk among Caucasians and/or African-Americans, but the polymorphisms may be implicated in different susceptibilities for lung cancer across different populations because of underlying genetic heterogeneity. We therefore conducted a study to examine this relationship in non-smoking Chinese. As a result , no significant associations were observed between SNPs and NSCLCs, whetehr of squamous cell or adenocarcinoma type. Results indicated polymorphisms of IL-7R, IL-13 and IL-15 are not major contributors to NSCLC susceptibility, although we can not rule out synergistic effects with cigarette smoke in NSCLC development in smoking Chinese. |
| Databáze: | OpenAIRE |
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