Development of a second generation group B meningococcal vaccine

Autor:	C E, Frasch, C T, Sacchi, M C, Brandiolone, V S, Vieiera, L C, Leite
Rok vydání:	1991
Předmět:	Bacterial Proteins Iron-Binding Proteins Periplasmic Binding Proteins Bacterial Vaccines Polysaccharides Bacterial Drug Evaluation Preclinical Humans Meningococcal Vaccines Serotyping Antibodies Bacterial Bacterial Capsules Bacterial Outer Membrane Proteins
Zdroj:	NIPH annals. 14(2)
ISSN:	0332-5652
Popis:	Outer membrane protein vaccines have now been demonstrated to be effective in prevention of group B Neisseria meningitidis disease, but the extent and duration of protection needs improvement. To develop a second generation outer membrane protein vaccine we have begun studies to evaluate vaccines containing iron regulated proteins in lipopolysaccharide depleted outer membrane vesicles. Since the iron regulated proteins are critical for in vivo survival, it is our working hypothesis that antibodies to these proteins will either be bactericidal or block iron uptake. Four representative strains were selected, and preliminary studies indicate that vaccines containing the iron regulated proteins are immunogenic in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::629312ba563d2e49f0367acd7680d5e8 https://pubmed.ncbi.nlm.nih.gov/1812436 Zobrazit plný text záznamu