| Autor: |
Daniel, Fleischmann, Sara, Maslanka Figueroa, Sebastian, Beck, Kathrin, Abstiens, Ralph, Witzgall, Frank, Schweda, Philipp, Tauber, Achim, Goepferich |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
ACS applied materialsinterfaces. 12(31) |
| ISSN: |
1944-8252 |
| Popis: |
Viral infection patterns often rely on precisely coordinated sequences of distinct ligand-receptor interactions, leading in many cases to an outstanding target cell specificity. A successful mimicry of viral targeting strategies to create more site-specific nanoparticles (NPs) would therefore require particle-cell interactions to also be adequately controllable. In the present study, hetero-multivalent block-copolymer NPs present their attached ligands in a sterically controlled manner to create a sequential NP-cell interaction similar to the cell infiltration strategy of human adenovirus type 2. Targeting renal mesangial cells, particles therefore initially bind angiotensin II receptor type 1 (AT1r) on the cell surface via a structurally flexible AT1r antagonist. After a mandatory spatial approach, particle endocytosis is realized via binding of immobile α |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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