Genetic and structural analysis of the

Autor:	Danelle, Wright, Makoto, Kiso, Yumiko, Saga
Rok vydání:	2020
Předmět:	Male Mice Knockout Sex Differentiation RNA-Binding Proteins Apoptosis Zinc Fingers Spermatozoa Recombinant Proteins Neoplasm Proteins Structure-Activity Relationship Protein Domains Cytoprotection Animals Amino Acid Sequence
Zdroj:	Development (Cambridge, England). 148(1)
ISSN:	1477-9129
Popis:	NANOS2 and NANOS3 are evolutionarily conserved RNA-binding proteins involved in murine germ cell development. NANOS3 is required for protection from apoptosis during migration and gonadal colonization in both sexes, whereas NANOS2 is male-specific and required for the male-type differentiation of germ cells. Ectopic NANOS2 rescues the functions of NANOS3, but NANOS3 cannot rescue NANOS2 function, even though its expression is upregulated in
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::626855b7ce0e072cd80728ac884405b5 https://pubmed.ncbi.nlm.nih.gov/33199444 Zobrazit plný text záznamu