Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain
| Autor: | Natalia, Cullell, Caty, Carrera, Elena, Muiño, Nuria-Paz, Torres-Aguila, Jara, Cárcel-Márquez, Jonathan, González-Sánchez, Cristina, Gallego-Fabrega, Jessica, Molina, Sarah, Besora, Javier, Sotoca, Maria-Teresa, Buongiorno, Jordi, Jiménez-Conde, Eva, Giralt-Steinhauer, Reyes, de Torres-Chacón, Joan, Montaner, Fernando, Mancha, Juan A, Cabezas, Joan, Martí-Fàbregas, Luis, Prats-Sánchez, Pol, Camps-Renom, Francisco, Purroy, Serafi, Cambray, María Del Mar, Freijo, Cristòfol, Vives-Bauzá, Silvia, Tur, Maria-Àngels, Font, Elena, López-Cancio, Maria, Hernandez-Perez, Victor, Obach, Ana, Calleja, Juan, Arenillas, Manuel, Rodríguez-Yáñez, José, Castillo, Tomas, Sobrino, Israel, Fernández-Cádenas, Jerzy, Krupinski |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Aged
80 and over Male Genetics of the nervous system Acenocoumarol Anticoagulants Polymorphism Single Nucleotide Genome-wide association studies Article Stroke Pharmacogenetics Spain Vitamin K Epoxide Reductases Humans Female cardiovascular diseases Prospective Studies Aged Cytochrome P-450 CYP2C9 Genome-Wide Association Study |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Acenocoumarol is an oral anticoagulant with significant interindividual dose variations. Variants in CYP2C9 and VKORC1 have been associated with acenocoumarol maintenance dose. We analysed whether any of the 49 polymorphisms in CYP2C9 and VKORC1 previously associated with acenocoumarol maintenance dose in a Genome-Wide Association study (GWAs) in Dutch population are associated with stroke recurrence, intracranial haemorrhage (ICH) and acenocoumarol maintenance dose in a Spanish population. We performed a GWAs using Human Core Exome-chip (Illumina) in 78 patients stroke patients treated with acenocoumarol for secondary prevention enrolled as part of the prospective investigator-initiated study (IIS) SEDMAN Study. Patients were followed-up a median of 12.8 months. Three and eight patients had recurrent stroke and ICH events, respectively. We found 14 of the 49 published variants associated with acenocoumarol maintenance dose (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|