| Autor: |
G, Lambert, D M, Thea, V, Pliner, R W, Steketee, E J, Abrams, P, Matheson, P A, Thomas, B, Greenberg, T M, Brown, M, Bamji, M L, Kalish |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
The Journal of pediatrics. 130(6) |
| ISSN: |
0022-3476 |
| Popis: |
Among a cohort of 152 infants perinatally infected with human immunodeficiency virus type 1, and their mothers, we correlated infant outcome with material CD4+ lymphocyte count and the presence of maternal acquired immunodeficiency syndrome near delivery. In a subset of 50 mother-infant pairs, we also correlated infant outcome with maternal quantitative viral burden as measured by the nucleic acid sequence based amplification system. We found that low maternal CD4+ cell count and high viral burden were associated with decreased time to category C disease or death in infants infected with human immunodeficiency virus type 1. In a multivariate analysis, high maternal viral load and maternal acquired immunodeficiency syndrome were independently associated with shorter time to category C disease or death in infants with human immunodeficiency virus type 1 infection. High viral load in pregnant women, independent of the presence of advanced maternal disease, appears to increase the risk of rapidly progressive disease in their infected offspring. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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