| Autor: |
C F, Ockenhouse, M, Ho, N N, Tandon, G A, Van Seventer, S, Shaw, N J, White, G A, Jamieson, J D, Chulay, H K, Webster |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
The Journal of infectious diseases. 164(1) |
| ISSN: |
0022-1899 |
| Popis: |
The CD36 and ICAM-1 glycoproteins on vascular endothelial cells have been implicated as cytoadherence receptors for Plasmodium falciparum-infected erythrocytes (IRBC). Adhesion of IRBC from Thai patients with uncomplicated and severe falciparum malaria to purified CD36 or ICAM-1 and to C32 melanoma cells was compared. All malaria isolates bound to solid phase-adsorbed CD36 and to fluid-phase 125I-labeled CD36. IRBC adhesion to purified ICAM-1 varied widely, and no correlation with clinical severity of disease was observed. The cytoadherent phenotype of IRBC was modulated by selective panning on plates coated with purified CD36 or ICAM-1. IRBC selected by panning on CD36+, ICAM-1+ melanoma cells bound to cells that express surface CD36 but not to CD36-deficient cells, indicating that CD36 exerts a strong selective pressure on the IRBC cytoadherent phenotype. IRBC adhesion to CD36 and ICAM-1 suggests that P. falciparum parasites may use these receptors in vivo to promote parasite survival and immune evasion. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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