| Autor: |
Bjork, James M., Burroughs, Thomas K., Franke, Laura M., Pickett, Treven C., Johns, Sade E., Gerard Moeller, F., Walker, William C. |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Arch Phys Med Rehabil |
| Popis: |
OBJECTIVE: To determine if elevated rapid-response impulsivity following blast exposure (as a putative marker of ventral prefrontal cortex (vPFC) damage) is predictive of future elevated affective symptomatology in blast-exposed service members. DESIGN: Longitudinal design with neurocognitive testing at initial assessment and one-year follow-up assessment of psychiatric symptomatology by telephone interview. SETTING: Veterans Administration medical centers and post-deployment assessment centers at military bases. PARTICIPANTS: Blast-exposed US military personnel (N=84) age 19–39. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Center for Epidemiological Studies-Depression Scale (CES-D) scores, post-traumatic stress disorder (PTSD) checklist (PCL-5) scores, and Alcohol Use Disorders Identification Test-C (AUDIT-C) scores at the 12-month follow-up telephone interview. RESULTS: After controlling for age and affective symptom scores reported at initial assessment, commission errors on the Continuous Performance Test-II of the initial assessment were predictive of higher symptom scores in CES-D and PCL-5 at follow-up, but were not predictive of AUDIT-C scores. CONCLUSION: Elevated rapid-response impulsivity, as a behavioral marker of reduced top-down frontocortical control, is a risk factor for elevated mood and PTSD symptoms over time in blast-exposed individuals. Future longitudinal studies with pre-deployment neurobehavioral testing could enable attribution of this relationship to blast-related vPFC damage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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