Can Quantitative CMR Tissue Characterization Adequately Identify Cardiotoxicity During Chemotherapy?: Impact of Temporal and Observer Variability
| Autor: | Mustafa A, Altaha, Mark, Nolan, Thomas H, Marwick, Emily, Somerset, Christian, Houbois, Eitan, Amir, Paul, Yip, Kim A, Connelly, Maria, Michalowska, Marshall S, Sussman, Bernd J, Wintersperger, Paaladinesh, Thavendiranathan |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Observer Variation Time Factors Heart Diseases Troponin I Magnetic Resonance Imaging Cine Reproducibility of Results Antineoplastic Agents Breast Neoplasms Middle Aged Trastuzumab Cardiotoxicity Predictive Value of Tests Case-Control Studies Natriuretic Peptide Brain Humans Anthracyclines Female Prospective Studies Biomarkers |
| Zdroj: | JACC. Cardiovascular imaging. 13(4) |
| ISSN: | 1876-7591 |
| Popis: | The purpose of this study was to investigate the effect of the temporal and observer variability of cardiac magnetic resonance (CMR)-measured native TBiomarkers and serial quantitative CMR tissue characterization may help identify early myocardial changes of CTRCD, but these parameters require both accuracy and reliability.A total of 50 participants (age 48.9 ± 12.1 years) underwent 3 CMR studies (1.5-T) and biomarker measurements (high-sensitivity troponin-I and B-type natriuretic peptide) at 3-month intervals: 20 with HER2-positive breast cancer (10 with and 10 without CTRCD), and 30 prospectively recruited healthy participants. TCompared with the patients without CTRCD, those with CTRCD had larger temporal change in native TThe temporal changes in both biomarkers and tissue characterization measures in individual patients overlap with the temporal variability in healthy participants and approach the minimal detectable temporal differences. While the accuracy of the parameters awaits further study, the temporal variability of these methods may pose challenges to routine clinical application in individual patients receiving cancer therapy. |
| Databáze: | OpenAIRE |
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