| Autor: |
Hiroko, Yukawa, Hiroaki, Inoue, Kaoru, Ogura, Shiho, Sakaguchi, Natsuko, Tanaka, Aya, Matsuoka, Mari, Kamimura, Akinori, Hattori, Asaka, Kodera, Yoshihiko, Naritaka, Akira, Hirano |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Gan to kagaku ryoho. Cancerchemotherapy. 46(7) |
| ISSN: |
0385-0684 |
| Popis: |
Ethinyl estradiol(EE2)therapy has been reported to be an effective endocrine therapy for postmenopausal hormone receptor-positive advanced breast cancer, especially in the supposed acquired resistance state. The current study retrospectively investigated the efficacy and safety of EE2 therapy in postmenopausal women with hormone receptor-positive advanced breast cancer who had previously undergone multiple endocrine therapies. Twelve patients were enrolled; median lines of endocrine therapies were seven before EE2. Median PFS was 4.8 months and median overall survival was 10.0 months. Grade 3 adverse event comprised of anorexia in only one patient. EE2 therapy may be considered effective and safe in hormone receptor-positive advanced breast cancer even in late-stage endocrine therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
