| Autor: |
P, Oehme, H, Hilse, R C, Görne, K, Hecht |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Die Pharmazie. 40(8) |
| ISSN: |
0031-7144 |
| Popis: |
In 1980 Oehme and co-workers [11] reported that Substance P (SP) has a dual effect on nociception, which is related to the pain threshold before SP administration. Our recent results showed that the N-terminal part of the SP sequence may be important to the hyperalgesic action, and the C-terminal part to the analgesic action of this peptide. The hyperalgesic effect of SP (and N-terminal fragments of SP) seems to be related to the "anti-stress" effect which was first demonstrated by Hecht and co-workers [5] and Oehme and co-workers [12]. Interaction of SP with opioid peptides could be the common reason of both the "anti-stress" effect and the hyperalgesic activity of SP. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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