Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist

Autor:	Matsuda, Kazuhiko, Hosie, Alastair M, Holyoke, Caleb W, Rauh, James J, Sattelle, David B
Jazyk:	angličtina
Rok vydání:	1999
Předmět:	Dieldrin Insecticides Dose-Response Relationship Drug Xenopus Membrane Potentials GABA Antagonists Insecticide Resistance Bridged Bicyclo Compounds Drosophila melanogaster Receptors GABA Chloride Channels Nitriles Oocytes Animals Special Report gamma-Aminobutyric Acid
Popis:	A novel tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes. Sensitivity to the block by KN244 of the response to 30 microM GABA (IC50=41.6 nM, wild-type RDLac) was reduced abut 100 fold (IC50=4.5 microM) in the dieldrin-resistant (RDLacA302S) form of RDL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::619645f40eab35b1e6cd3903968d4ae0 https://europepmc.org/articles/PMC1760657/ Zobrazit plný text záznamu