| Autor: |
Jun, He, Jian-fang, Feng, Le-le, Zhang, Wei-gen, Lu, Shi-xiang, Hou |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 30(2) |
| ISSN: |
1001-5302 |
| Popis: |
To investigate lyophilization of SM-SLN.The parameters of lyophilization process was optimized. In addition, the protective effect of various types and concentrations of cryoprotectants were tested by shape, colour and disparity.The mixture of 2% lactose and 2% glucose could better prevent nanoparticles from aggregating, the optimal lyophilization process was followed: precooled at -45 degrees C for 10 hr; primary drying at -25 degrees C for 5 hr; secondary drying at 10 degrees C for 3 hr; finally drying at 30 degrees C for 6 hr.Changes in particle size distribution during lyophilization could be minimized by optimizing the parameters of the lyophilization process and adding supporting agent. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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