| Autor: |
V I, Masycheva, V S, Shirinskiĭ, N M, Starostina, V S, Kozhevnikov, I V, Meledina, L M, Novikova, E V, Meniaeva, N V, Kristosova, N I, Shevchuk, E V, Evsiukova, E D, Danilenko, N M, Pustoshilova, V A, Kozlov |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Vestnik Rossiiskoi akademii meditsinskikh nauk. (11) |
| ISSN: |
0869-6047 |
| Popis: |
Clinical trails of Befnorin based on the human recombinant TNF-beta elaborated at the Research Design and Technology Institute of Biologically Active Substances, "Vector" State Research Center of Virology and Biotechnology, were carried out on healthy volunteers in compliance with a decision passed by the Committee of Medical and Immunobiological Preparations, Russia's Health Ministry. Single Befnorin doses of 5-10(4) U, 10(5) U, 5-10(5) U, and 10(6) U were administered as intramuscular injections. Clinical, biochemical and immunological parameters were registered for 7 days after a single dose. The drug had an impact on the below immunity indices: Fc-phagocytosis of monocytes, migration index and migration inhibition index. The dose of 10(5) U was proven to be most effective and safe. Supposedly, the drug can be effective in the treatment of herpetic diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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