Antifungal activity of some substituted pyrimidines

Autor: J D, McChesney, M, Gonzalez-Sierra
Rok vydání: 2013
Zdroj: Pharmaceutical research. 2(3)
ISSN: 0724-8741
Popis: Several 6-chloro-5-nitropyrimidines were synthesized, and their antifungal activity was tested. Some derivatives were equipotent or superior to amphotericin B in vitro but their relatively high toxicity in mice and their chemical instability discourage further evaluation.
Databáze: OpenAIRE