| Autor: |
Maiko, Sezaki, Subinoy, Biswas, Sayuri, Nakata, Motohiko, Oshima, Shuhei, Koide, Nicole Pui Yu, Ho, Nobukazu, Okamoto, Takeshi, Miyamoto, Atsushi, Iwama, Hitoshi, Takizawa |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Stem cells and development. 30(14) |
| ISSN: |
1557-8534 |
| Popis: |
Human mesenchymal stem/stromal cells (hMSCs), when engrafted into immunodeficient mice, can form ectopic bone organs with hematopoietic stem cell (HSC) supportive functions. However, the ability to do so, through a cartilage intermediate, appears limited to 30% of donor bone marrow samples. In this study, we characterize the heterogeneous nature of hMSCs and their ability to efficiently form humanized ossicles observed in "good donors" to correlate with the frequency and functionality of chondrocyte progenitors. Flow cytometry of putative hMSC markers was enriched in the CD271 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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