Protective effect of low molecular-weight seleno-aminopolysaccharides against H
| Autor: | Zheng-Shun, Wen, Li, Ma, Xing-Wei, Xiang, Zhen, Tang, Rong-Fa, Guan, You-Le, Qu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Glutathione Peroxidase
Kelch-Like ECH-Associated Protein 1 Cell Death L-Lactate Dehydrogenase NF-E2-Related Factor 2 Superoxide Dismutase Sus scrofa Hydrogen Peroxide Catalase Protective Agents Antioxidants Cell Line Molecular Weight Oxidative Stress Selenium Enterocytes Gene Expression Regulation Cytoprotection Polysaccharides Malondialdehyde Inactivation Metabolic Animals Lipid Peroxidation RNA Messenger |
| Zdroj: | International journal of biological macromolecules. 112 |
| ISSN: | 1879-0003 |
| Popis: | Organoselemium compounds possess strong antioxidant activity as well as protecting cells from DNA damage, mitochondrial injury, lipid peroxidation, protein denaturation and cell death. Herein, we used an in vitro oxidative model to further investigate the antioxidant effects of a novel organoselemium compound, low molecular-weight seleno-aminopolysaccharides (LSA) in intestinal porcine epithelial cells (IPEC-1), and the molecular mechanisms of these effects. Analysis by MTT assay showed that LSA could significantly increase the viability of IPEC-1 cells compared to cells exposed to H |
| Databáze: | OpenAIRE |
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