| Autor: |
M, Makhseed, R, Raghupathy, S, El-Shazly, F, Azizieh, J A, Al-Harmi, M M K, Al-Azemi |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
American journal of reproductive immunology (New York, N.Y. : 1989). 49(5) |
| ISSN: |
1046-7408 |
| Popis: |
The objective of this study was to determine the levels of cytokines produced by maternal peripheral blood mononuclear cells (PBMC) upon stimulation with a mitogen, with autologous placental cells and with a trophoblast antigen extract.Peripheral blood mononuclear cells from 54 women with a history of successful pregnancy and 30 women undergoing preterm delivery (PTD) were stimulated with the mitogen and antigens, and the cytokine levels in mitogen-stimulated culture supernatants assessed.Significantly higher levels of the type 1 cytokines, interferon (IFN)-gamma and interleukin (IL)-2, were produced by the PTD group than by the normal pregnancy group, which on the contrary showed significantly greater production of the type 2 cytokines, IL-4, IL-5 and IL-10. A comparison of the ratios of type 2 to type 1 cytokines is indicative of a type 1 cytokine bias in PTD.These data are suggestive of a maternal type 1 cytokine bias in PTD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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