The prognostic significance of neuroendocrine markers and carcinoembryonic antigen in patients with resected stage I and II non-small cell lung cancer
| Autor: | S L, Graziano, A H, Tatum, N B, Newman, A, Oler, L J, Kohman, L J, Veit, G P, Gamble, M J, Coleman, S, Barmada, S, O'Lear |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Aged 80 and over Antigens Differentiation T-Lymphocyte Male Lung Neoplasms Synaptophysin Middle Aged Prognosis Survival Analysis Carcinoembryonic Antigen Carcinoma Non-Small-Cell Lung Phosphopyruvate Hydratase Biomarkers Tumor Chromogranins Chromogranin A Humans Female Aged Neoplasm Staging Retrospective Studies |
| Zdroj: | Cancer research. 54(11) |
| ISSN: | 0008-5472 |
| Popis: | Non-small cell lung cancer with neuroendocrine differentiation may represent a subset of patients with a more aggressive (like small cell lung cancer) or less aggressive (like carcinoid) biological behavior. To investigate their prognostic significance, immunohistochemical stains for 4 neuroendocrine markers (neuron-specific enolase, chromogranin A, Leu-7, and synaptophysin) and carcinoembryonic antigen (CEA) were studied in 260 patients with surgically resected stage I and II non-small cell lung cancer. The following percentages of cases were positive for each marker: neuron-specific enolase, 70.0%; chromogranin A, 14.2%; Leu-7, 7.7%; synaptophysin, 11.2%; and CEA, 68.5%. Sixty-one (23.5%) were positive foror = 2 neuroendocrine markers. When compared to adenocarcinoma, squamous cell carcinoma displayed lower positivity for CEA andor = 2 neuroendocrine markers. There was no significant difference in stage, site of relapse (distant versus local), disease-free, or overall survival for each marker individually or for those withor = 2 neuroendocrine markers. Multivariate analysis showed that higher nodal stage (N1 versus N0), tumor stage (T2 versus T1), older age, and the presence of mucin predicted for poorer overall survival. Neuroendocrine markers and CEA were not of prognostic significance in this group of patients with resected stage I and II non-small cell lung cancer. |
| Databáze: | OpenAIRE |
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