| Autor: |
Rui-mei, Han, Xiang-yang, Zhang, Zhi-tao, Yan, Ju-hong, Zhang, Yan-ying, Guo, Hong-mei, Wang, Ling, Zhou, Nan-fang, Li |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Zhonghua xin xue guan bing za zhi. 40(12) |
| ISSN: |
0253-3758 |
| Popis: |
To investigate the association between genetic variations of the six transmembrane protein of prostate 2 (STAMP2) and obesity in Xinjiang Uygur population.A total of 2332 Uygur subjects (1455 obesity and 877 non-obesity control subjects) were included in this case-control study based on epidemiological survey. Genetic variations of STAMP2 gene functional region were sequenced. The representative variations selected were genotyped by TaqMan-PCR method.Twenty genetic variations, including 14 novel variations, were identified. The genotype distributions of the control group and obesity group were in the Hardy-Weinberg equilibrium (both P0.05). The frequency of AA of rs1981529 (67.6% vs. 62.8%, P0.05) and the frequency of G-A-G haplotype (62.4% vs. 58.9%, P0.05) in obesity group were significantly higher than that in controls while the frequency of A-G-G haplotype was significantly lower in the obesity patients than that in the control group (17% vs. 20%, P0.05). After adjusting age, sex, smoking and drinking, logistic regression analysis showed that the AA genotype of rs1981529 (OR: 1.276, 95%CI: 1.049 - 1.552; P0.05) and the G-A-G haplotype (OR: 1.356, 95%CI: 1.007 - 1.862, P0.05) were the independent risk factors for obesity in this cohort.The AA genotype of rs1981529 and G-A-G haplotype are associated with obesity in Uygur population of Xinjiang. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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