| Autor: |
A E, Baldwin, M R, Holahan, K, Sadeghian, A E, Kelley |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Behavioral neuroscience. 114(1) |
| ISSN: |
0735-7044 |
| Popis: |
The effect of microinfusion of the N-methyl-D-aspartate (NMDA) antagonist 2-amino-5-phosphonopentanoic acid (AP-5) into the amygdala, medial prefrontal cortex, and dorsal and ventral subiculum on acquisition of a lever-pressing task for food in rats was examined. Serial transmission between the basolateral amygdala and nucleus accumbens core was also examined in an asymmetric infusion design. AP-5 administered bilaterally into either the amygdala or medial prefrontal cortex markedly impaired learning, whereas administration into the dorsal or ventral subiculum had no effect. Unilateral infusion of AP-5 into either the nucleus accumbens core or amygdala was also sufficient to impair learning. These data provide novel evidence for NMDA receptor-dependent plasticity within corticostriatal networks in the acquisition of appetitive instrumental learning. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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