New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with

Autor: Mohammed M, Alanazi, Hazem, Elkady, Nawaf A, Alsaif, Ahmad J, Obaidullah, Hamad M, Alkahtani, Manal M, Alanazi, Madhawi A, Alharbi, Ibrahim H, Eissa, Mohammed A, Dahab
Rok vydání: 2021
Zdroj: RSC advances. 11(48)
ISSN: 2046-2069
Popis: A new series of 3-methylquinoxaline-based derivatives having the same essential pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for their antiproliferative activities against two human cancer cell lines, MCF-7 and HepG-2. Compounds 15b and 17b demonstrated a significant antiproliferative effect with IC
Databáze: OpenAIRE