| Autor: |
R, Carstam, C, Brinck, B, Fornstedt, H, Rorsman, E, Rosengren |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Acta dermato-venereologica. 70(5) |
| ISSN: |
0001-5555 |
| Popis: |
5-S-Cysteinyldopac, a compound hitherto demonstrated only in brain tissue, has been isolated and quantified in urine. The urines from 12 individuals were found to contain 20 +/- 9.1 micrograms 5-S-cysteinyldopac/24 hours. Incubation of 5-S-cysteinyldopamine with MAO-containing tissue did not give any formation of 5-S-cysteinyldopac, indicating that this compound is formed by nucleophilic addition of cysteine directly to dopac. The findings give further evidence for a small but significant non-specific oxidation of endogenous catechol derivatives in vivo, a fact to be considered when using 5-S-cysteinyldopa as a measure of pigment metabolism. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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