Dynamic Input Conductances Shape Neuronal Spiking1,2
| Autor: | Drion, Guillaume, Franci, Alessio, Dethier, Julie, Sepulchre, Rodolphe |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | eNeuro |
| ISSN: | 2373-2822 |
| Popis: | Reliable neuron activity is ensured by a tight regulation of the ion channels that resides in the neuron’s membrane. Understanding the causal mechanisms that relate this regulation to physiological and pathological neuronal activity is a necessary step for developing efficient therapies for neurological diseases associated with abnormal nervous system activity. Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness, and homeostasis of neuronal signalling. The paper proposes that this question can be addressed through the analysis of dynamic input conductances. Those voltage-dependent curves aggregate the concomitant activity of all ion channels in distinct timescales. They are shown to shape the current−voltage dynamical relationships that determine neuronal spiking. We propose an experimental protocol to measure dynamic input conductances in neurons. In addition, we provide a computational method to extract dynamic input conductances from arbitrary conductance-based models and to analyze their sensitivity to arbitrary parameters. We illustrate the relevance of the proposed approach for modulation, compensation, and robustness studies in a published neuron model based on data of the stomatogastric ganglion of the crab Cancer borealis. |
| Databáze: | OpenAIRE |
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