[Immune and genetic markers revealed in women working in technical rubber goods production]
| Autor: | K G, Starkova, O V, Dolgikh, A V, Krivtsov, O A, Bubnova, V A, Horoshavin |
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| Rok vydání: | 2016 |
| Předmět: |
Polymorphism
Genetic Genotype T-Lymphocytes Immunoglobulins Apoptosis Air Pollutants Occupational Receptors Tumor Necrosis Factor Russia Immune System Phenomena Phagocytosis Antigens CD Case-Control Studies Chemical Industry Occupational Exposure Mutation Noise Occupational Humans Female Rubber fas Receptor Alleles Biomarkers |
| Zdroj: | Meditsina truda i promyshlennaia ekologiia. (12) |
| ISSN: | 1026-9428 |
| Popis: | Medical examination covered female workers engaged into chemical production of technical rubber goods, under combined exposure to chemicals (nitrogen oxides, carbon oxide) and noise exceeding MAC by 3.7-27.5%. Findings are increased phagocytary activity, lower level of serum IgM and IgG, suppressed expression of CD25 and CD95 T-cell receptors, and slower apoptosis induced via Fas receptor--all those indicators associated with work conditions. The disorders revealed are actualized on a basis of genetic variability features of the females, that is characterized by prevalence of mutant allels of FAS and TNFR genes with minor homozygous phenotype. |
| Databáze: | OpenAIRE |
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