C-Terminal Cu
| Autor: | Dinendra L, Abeyawardhane, Denver R, Heitger, Ricardo D, Fernández, Ashley K, Forney, Heather R, Lucas |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | ACS chemical neuroscience. 10(3) |
| ISSN: | 1948-7193 |
| Popis: | The structurally dynamic amyloidogenic protein α-synuclein (αS) is universally recognized as a key player in Parkinson's disease (PD). Copper, which acts as a neuronal signaling agent, is also an effector of αS structure, aggregation, and localization in vivo. In humans, αS is known to carry an acetyl group on the starting methionine residue, capping the N-terminal free amine which was a known high-affinity Cu |
| Databáze: | OpenAIRE |
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