Essential role of NbNOG1 in ribosomal RNA processing

Autor:	Jiangbo, Guo, Shaojie, Han, Jinping, Zhao, Cuihua, Xin, Xiyin, Zheng, Yule, Liu, Yan, Wang, Feng, Qu
Rok vydání:	2018
Předmět:	Trypanosoma RNA Ribosomal Humans Gene Silencing Ribosomes Cell Nucleolus
Zdroj:	Journal of integrative plant biology. 60(11)
ISSN:	1744-7909
Popis:	Nucleolar GTP-binding protein 1 (NOG1) is a highly conserved GTPase first reported in Trypanosoma as required for ribosome biogenesis. We characterized NbNOG1, a Nicotiana benthamiana NOG1 ortholog sharing more than 45% amino acid identity with Trypanosoma, yeast, and human NOG1. N. benthamiana plants silenced for NbNOG1 were stunted and produced sterile flowers. NbNOG1 is functionally interchangeable with yeast NOG1 (ScNOG1), rescuing yeast lethality caused by loss of ScNOG1. Finally, NbNOG1 silencing caused over-accumulation of pre-rRNA processing intermediates, and concomitant loss of mature rRNAs. Collectively, these data support a role for NbNOG1 in ribosomal RNA processing.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5fe484414ddd49de1ad12980535a107f https://pubmed.ncbi.nlm.nih.gov/30252198 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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