| Autor: |
E A, Fraser-Andrews, J M, McGregor, T, Crook, L, Brookes, E, Calonje, S J, Whittaker |
| Rok vydání: |
2001 |
| Předmět: |
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| Zdroj: |
Clinical and experimental dermatology. 26(8) |
| ISSN: |
0307-6938 |
| Popis: |
We report a case of Sézary syndrome in a patient who was in the immediate vicinity of the Chernobyl nuclear reactor accident 18 months prior to presentation. A complex, frameshift p53 gene mutation was subsequently identified in tumour tissue, consisting of an 8-base pair deletion and a T--G point mutation in exon 7. This is characteristic of damage caused by ionizing radiation, which suggests a causal link between exposure to ionizing radiation and the subsequent development of Sézary syndrome, a rare form of T-cell leukaemia/lymphoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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