Inhibition of peroxynitrite dependent tyrosine nitration by hydroxycinnamates: nitration or electron donation?

Autor:	A S, Pannala, R, Razaq, B, Halliwell, S, Singh, C A, Rice-Evans
Rok vydání:	1998
Předmět:	Caffeic Acids Nitrates Coumaric Acids Free Radicals Spectrophotometry Tyrosine Free Radical Scavengers Chlorogenic Acid Chromans Antioxidants Chromatography High Pressure Liquid
Zdroj:	Free radical biologymedicine. 24(4)
ISSN:	0891-5849
Popis:	Peroxynitrite is a cytotoxic species generated by the reaction between superoxide and nitric oxide. In this study the ability of hydroxycinnamate antioxidants to decrease peroxynitrite-mediated nitration of tyrosine was investigated. The results obtained show that all compounds were able to inhibit nitration of tyrosine. The potency of inhibitory activity was in the order; caffeic acidor = chlorogenic acidor = ferulic acidp-coumaric acidocoumaric acidm-coumaric acid. Trolox, which was included in the study for comparative purposes, had an activity between that of ferulic acid and p-coumaric acid. The data obtained suggest that hydroxycinnamates can act by one of two possible mechanisms: preferential nitration for monophenolates and electron donation by catecholates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5f758b8f33b6b45e9bf8a74832f32dc0 https://pubmed.ncbi.nlm.nih.gov/9559872 Zobrazit plný text záznamu Full Text from ScienceDirect