| Autor: |
Dexter P, Mendoza, Jessica J, Lin, Marguerite M, Rooney, Tianqi, Chen, Lecia V, Sequist, Alice T, Shaw, Subba R, Digumarthy |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
AJR Am J Roentgenol |
| ISSN: |
1546-3141 |
| Popis: |
OBJECTIVE: ALK rearrangements are an established targetable oncogenic driver in non-small cell lung cancer (NSCLC). This study’s goal was to determine the imaging features of the primary tumor and metastatic patterns in advanced ALK-rearranged (ALK+) NSCLC that may be different from those in EGFR-mutant (EGFR+) or EGFR/ALK-wild-type (EGFR-/ALK-) NSCLC. METHODS: Patients with advanced ALK+, EGFR+, or EGFR-/ALK- NSCLC were retrospectively identified. Two radiologists concurrently assessed the imaging features of the primary tumor and the distribution metastases in these patients. RESULTS: We identified a cohort of 333 patients with metastatic NSCLC (119 ALK+, 116 EGFR+, and 98 EGFR-/ALK-). Compared to EGFR+ and EGFR-/ALK- NSCLC, the primary tumor in ALK+ NSCLC was more likely to be in the lower lobes (ALK+=53%, EGFR+=34%, EGFR-/ALK-=36%; p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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