Molecular aspects concerning antigen oligopeptide selection by MHC class I molecules

Autor:	D, Drugărin, Z, Simon, T, Sulea, C A, Tatu
Rok vydání:	1993
Předmět:	HIV Antigens T-Lymphocytes Molecular Sequence Data Antigen-Presenting Cells Gene Products env Genes MHC Class I Ligands HIV Envelope Protein gp160 Antigens Surface HIV-1 Humans Amino Acid Sequence Antigens Protein Precursors Oligopeptides
Zdroj:	Roumanian archives of microbiology and immunology. 52(4)
ISSN:	1222-3891
Popis:	T cells can recognize the antigen only if it is associated with self MHC molecules on the surface of antigen presenting cells (APC). There are several characteristic parameters defining interaction of MHC molecule with antigenic peptides giving circumstances for specific antigen presentation and an individualized immune response. Here are assessed some size and conformational parameters of the peptides presented by MHC class I molecules-lengths, widths, van der Waals volumes and surfaces-using COSMIC 2.0 software. The peptides derived from HIV gp 160 are obtained from literature and are known to be active and inactive in a cytotoxicity assay. An increased tendency for beta- or beta-like structures and volumes close to those of the MHC binding site are encountered in the case of active peptides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5f3dd9a79d91b99810ce444c41240e94 https://pubmed.ncbi.nlm.nih.gov/7827364 Zobrazit plný text záznamu