| Autor: |
N, Ustun, F, Tok, U, Kalyoncu, S, Motor, R, Yuksel, A E, Yagiz, H, Guler, A D, Turhanoglu |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Acta reumatologica portuguesa. 39(2) |
| ISSN: |
2184-8777 |
| Popis: |
To determine the serum Dickkopf-related protein 1 (Dkk-1) and sclerostin levels, and their relationship to structural damage and disease activity in patients with ankylosing spondylitis (AS), as well as to compare the serum Dkk-1 and sclerostin levels in patients receiving and not receiving anti-TNF-a treatment. MATERIALS AND METHOds: This cross-sectional study included 44 AS patients and 41 healthy age- and gender- -matched controls. Demographic data, disease activity parameters, and Bath Ankylosing Spondylitis Radiologic Index (BASRI) scores were recorded. Serum Dkk-1 and sclerostin levels were measured using commercially available ELISA.Serum Dkk-1 levels were lower (P0.05) and sclerostin levels were significantly lower (P0.05) in the AS patients than in the controls. Dkk-1 and sclerostin levels were similar in the patients that did and didn't receive anti-TNF-a treatment, and in the patients with active and inactive disease (P0.05). There wasn’t a correlation between serum Dkk-1 or sclerostin levels, and disease activity indices (P0.05). BASRI scores did not correlate with serum Dkk-1 or sclerostin levels (P0.05). DISCUSSIOn: Sclerostin expression is impaired in AS, but this is not the case for Dkk-1. The lack of an association between Dkk-1 or sclerostin levels, and anti-TNF-a treatment, disease activity indices, and radiological damage might indicate that neither the Dkk-1 nor sclerostin level induce inflammation and radiological damage in AS patients. Pathologic bone formation in AS might be due to molecular dysfunction of sclerostin and Dkk-1 at the cellular level. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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