| Autor: |
D A, Basarab, V L, Kozhura, A M, Golubev, M I, Timkina, V V, Moroz |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Anesteziologiia i reanimatologiia. (6) |
| ISSN: |
0201-7563 |
| Popis: |
The studies were carried out on 76 albino noninbred male rats weighing 210-420 g. Ischemia of a jejunal segment was induced by applying a tourniquet to the base of a loop with the mesentery until the circulation fully stopped. Nonoxygenated perfluorane (an experimental group) or saline solution (a control group) was injected in a dose of 0.8-1.0 ml/100 g intraarterially 15 minutes before the termination of ischemia. During 90 min of reperfusion, there was a progressive decline of blood pressure (BP) with reference to the ischemic period by 39.8 +/- 20.9 and 20.8 +/- 14.6% in an experimental and control groups, respectively (p0.05). Biomicroscopy indicated that by min 5 of reperfusion, a relative reduction in the diameter (50-400 microns) of nutrient mesenteric arteries was half as large as that in the control group (24.0 +/- 5.5 and 45.1 +/- 3.6%; p0.05); by min 90, differences decreased (41.5 +/- 4.2 and 50.3 +/- 2.8%, respectively; por = 0.05). In the experimental group, perfluorane prevents the development of irreversible structural changes in the reperfusion period: the remaining cryptal epithelium is a source of regeneration of the integumentary epithelium of forming villi of the small intestinal mucosa. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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