| Autor: |
Mads Bisgaard, Bengtsen, Esben Søvsø Szocska, Hansen, Rasmus Stilling, Tougaard, Mads Dam, Lyhne, Nikolaj Fibiger, Rittig, Julie, Støy, Niels, Jessen, Christian Østergaard, Mariager, Hans, Stødkilde-Jørgensen, Niels, Møller, Christoffer, Laustsen |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Experimental physiology. 106(12) |
| ISSN: |
1469-445X |
| Popis: |
What is the central question of this study? Is it possible to combine the hyperpolarized magnetic resonance technique and the hyperinsulinaemic clamp method in order to evaluate skeletal muscle metabolism in a large animal model? What is the main finding and its importance? The logistical set-up is possible, and we found substantial increments in glucose infusion rates representing skeletal muscle glucose uptake but no differences in ratios of [1-In skeletal muscle, glucose metabolism is tightly regulated by the reciprocal relationship between insulin and adrenaline, with pyruvate being at the intersection of both pathways. Hyperpolarized magnetic resonance (hMR) is a new approach to gain insights into these pathways, and human trials involving hMR and skeletal muscle metabolism are imminent. We aimed to combine the hyperinsulinaemic clamp technique and hMR in a large animal model resembling human physiology. Fifteen anaesthetized pigs were randomized to saline (control group), hyperinsulinaemic euglycaemic clamp technique (HE group) or hyperinsulinaemic hypoglycaemic clamp technique (HH group). Skeletal muscle metabolism was evaluated by hyperpolarized [1 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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