| Autor: |
Jocelyn, Widagdo, Saumya, Udagedara, Nishita, Bhembre, Jing Zhi Anson, Tan, Lara, Neureiter, Jie, Huang, Victor, Anggono, Mihwa, Lee |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Open biology. 12(9) |
| ISSN: |
2046-2441 |
| Popis: |
Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation of SFPQ are associated with the pathophysiology of amyotrophic lateral sclerosis (ALS). We have previously reported that zinc mediates SFPQ polymerization and promotes the formation of cytoplasmic aggregates in neurons. Here we characterize two familial ALS (fALS)-associated |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
