| Autor: |
I E, Mutule, F K, Mutulis, S Kh, Rozite, E A, Porunkevich, M P, Ratkevich |
| Rok vydání: |
1989 |
| Předmět: |
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| Zdroj: |
Bioorganicheskaia khimiia. 15(3) |
| ISSN: |
0132-3423 |
| Popis: |
Four cyclic derivatives of des-Arg9[Leu8]bradykinin have been obtained by classical methods of peptide chemistry. They are cyclo-(-X-Arg-Pro-Pro-Gly-Phe-Gly-Pro-Leu-), where X=Lys or none, and cyclo-(Y-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu-), where Y= Lys or Orn. Peptide bonds have been formed by the pentafluorophenylester method, and cyclization has been carried out in a diluted dioxane solution with 40% yield. Subsequent cleavage of protecting groups was made by treatment with hydrogen fluoride. The products obtained were purified by droplet counter-current chromatography. These substances liberate histamine from the rat mast cells comparably to bradykinin and fail to produce myotripic and vascular effects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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