| Autor: |
Debora, Petroni, Antonietta, Bartoli, Simona, Rapposelli, Maria, Digiacomo, Silvia, Burchielli, Giulia, Nesi, Annalina, Lapucci, Silvia, Pardini, Sabrina, Fucci, Marco, Macchia, Piero A, Salvadori, Luca, Menichetti |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Molecular imaging and biology. 18(6) |
| ISSN: |
1860-2002 |
| Popis: |
The plasma membrane P-glycoprotein (Pgp) is an efflux transporter involved in multidrug resistance and in the onset of neurodegenerative disease. Its function and most mechanisms of action are still under investigation. We developed a C-11-labeled 2-arylethylphenylamine-([The synthetic procedure and the quality control of the selected lead compound, [In vivo dynamic imaging was consistent with the results of ex vivo extraction on explanted organs. An adequate stability for in vivo studies, as well as a high activity of [The suitable pharmacokinetics and the specificity tested in the pre-treated animals have indicated the potentiality of this AEPH derivative to act as Pgp ligand, providing new opportunities for further studies on expression and function of this important efflux transporter in the fields of neurology and oncology. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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