Long-acting granulocyte colony-stimulating factor pegfilgrastim (lipegfilgrastim) for stem cell mobilization in multiple myeloma patients undergoing autologous stem cell transplantation
| Autor: | Ivetta, Danylesko, Rina, Sareli, Nira, Varda-Bloom, Ronit, Yerushalmi, Noga, Shem-Tov, Hila, Magen, Avichai, Shimoni, Arnon, Nagler |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Filgrastim Hematopoietic Stem Cell Transplantation Middle Aged Hematopoietic Stem Cells Transplantation Autologous Hematopoietic Stem Cell Mobilization Immunophenotyping Polyethylene Glycols Treatment Outcome T-Lymphocyte Subsets Granulocyte Colony-Stimulating Factor Blood Component Removal Humans Female Multiple Myeloma Aged |
| Zdroj: | International journal of hematology. 114(3) |
| ISSN: | 1865-3774 |
| Popis: | Autologous stem cell transplantation (ASCT) is a standard of care in newly-diagnosed multiple myeloma (MM) patients. Several studies before the introduction of novel therapies in MM, demonstrated a pegylated G-CSF to be successful in mobilizing peripheral blood stem cells (PBSCs). Lipegfilgrastim is a novel long-acting G-CSF that is produced by the conjugation of a single 20-kDa polyethelene glycol to the natural O-glycosylation site of G-CSF. Twenty-four MM patients were included for PBSCs mobilization with a single SC injection of 6 mg lipegfilgrastim. PBSC collection was started when the CD34 |
| Databáze: | OpenAIRE |
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