| Autor: |
Justin J, Bailey, Lena, Kaiser, Simon, Lindner, Melinda, Wüst, Alexander, Thiel, Jean-Paul, Soucy, Pedro, Rosa-Neto, Peter J H, Scott, Marcus, Unterrainer, David R, Kaplan, Carmen, Wängler, Björn, Wängler, Peter, Bartenstein, Vadim, Bernard-Gauthier, Ralf, Schirrmacher |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
ACS chemical neuroscience. 10(6) |
| ISSN: |
1948-7193 |
| Popis: |
The tropomyosin receptor kinase TrkA/B/C family is responsible for human neuronal growth, survival, and differentiation from early nervous system development stages onward. Downregulation of TrkA/B/C receptors characterizes numerous neurological disorders including Alzheimer's disease (AD). Abnormally expressed Trk receptors or chimeric Trk fusion proteins are also well-characterized oncogenic drivers in a variety of neurogenic and non-neurogenic human neoplasms and are currently the focus of intensive clinical research. Previously, we have described the clinical translation of a highly selective and potent carbon-11-labeled pan-Trk radioligand and the preclinical characterization of the optimized fluorine-18-labeled analogue, [ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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