| Autor: |
A P, Alliluev, O V, Kotel'nikova, V I, Kuvakina, G V, Bobyleva, I L, Gofman, Iu G, Kaz'mina |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Zhurnal mikrobiologii, epidemiologii i immunobiologii. (4) |
| ISSN: |
0372-9311 |
| Popis: |
This work deals with the problem of relationship between the molecular parameters of group A meningococcal polysaccharide and its immunological effectiveness for laboratory animals and humans. The depolymerization of group A polysaccharide contained in the vaccine leads to a decrease in its capacity of inducing the production of hemagglutinating (19S and 7S) and bactericidal IgA antibodies in humans, as well as inducing an increase in the number of cells producing IgA antibodies in the spleen of immunized mice and the appearance of circulating IgA antibodies in their sera. As shown in this investigation, fully developed immune response to group A meningococcal vaccine may be achieved in humans only if the content of group A high-molecular polysaccharide in the vaccine is not less than 70%. Mice have been recommended as an experimental model for the prognostication of the effectiveness of meningococcal polysaccharide vaccines and for their control in the process of manufacture instead of currently used titration of bacteriolysins in the sera of immunized humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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