| Autor: |
Monica R, Cesinger, Oluwasegun I, Daramola, Lucy M, Kwiatkowski, Michelle L, Reniere |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Infection and immunity. 90(10) |
| ISSN: |
1098-5522 |
| Popis: |
Listeria monocytogenes is a Gram-positive facultative anaerobe and an excellent model pathogen for investigating regulatory changes that occur during infection of a mammalian host. SpxA1 is a widely conserved transcriptional regulator that induces expression of peroxide-detoxifying genes in L. monocytogenes and is thus required for aerobic growth. SpxA1 is also required for L. monocytogenes virulence, although the SpxA1-dependent genes important in this context remain to be identified. Here, we sought to investigate the role of SpxA1 in a tissue culture model of infection and made the surprising discovery that Δ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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